Epigenetics Research Tools
Epigenetics is the study of chromatin-based phenomena and heritable changes in gene expression that do not involve changes to the underlying DNA sequence - a change in phenotype without a change in genotype. Epigenetic change is a regular and natural occurrence but can also be influenced by several factors including age, the environment/lifestyle and disease state. Researchers can start out with little more than DNA, histone proteins or chromatin and investigate fascinating topics such as cancer epigenetics, neuropsychiatric disorders, nutritional development, metabolic diseases and more.
Innovative technologies and products developed by our partners Epigentek and EpiCypher including kits for the analysis of DNA methylation and chromatin remodeling are offered to facilitate epigenetics research and expand the potential for biomarker discovery.
Benefit from rapid and efficient preparation of DNA, proteins and chromatin.
Choose from a large number of kits developed for gene-specific or global DNA methylation analysis.
Analyze m6A or 5-mC RNA methylation in total RNA samples isolated from cells or tissue.
Screen and measure up to 21 different H3 or 10 different H4 modifications in ELISA-like kits.
Screen effector protein, antibody and enzyme interactions with 296 combinatorially-modified and biotinylated histone peptides.
Select from the largest selection of biotinylated histone peptides, over 95 modifications, single or multiple, up to 8 per peptide.
Employ fully defined and homogeneous recombinant nucleosomes incorporating different DNA and histone modifications, site mutations, and histone variants. More than 70 post translational modifications (PTM) available.
Gain further insight into the dynamic interactions between transcription proteins and components of chromatin by using chromatin immunoprecipitation (ChIP).
Apply SNAP-ChIP DNA-barcoded recombinant designer nucleosomes (dNucs) as next-generation spike-ins for chromatin immunoprecipitation (ChIP).
Apply best-in-class SNAP-ChIP Certified Antibodies with exquisite target specificity, less than 20% cross-reactivity and more than 5% IP efficiency.
Study chromatin remodeling using EpiDyne nucleosome substrates available for two readouts: Restriction Enzyme Accessibility (REA) and FRET.
Study the dynamic effects of chromatin structure on gene expression.
Construct high-quality NGS libraries from low quantity or difficult samples for Genomic DNA Seq, DNA Bisulfite Seq, ChIP Seq, Post Bisulfite Seq or RNA Bisulfite Seq.